Monitor Intently (two)pentobarbital will decrease the extent or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Sturdy CYP3A4 inducers might decrease suvorexant efficacy; if enhanced suvorexant dose required, will not exceed 20 mg/daypentobarbital will reduce the level or impact of repaglin